Oregon Grape
Mahonia aquifolium
Description
overall appearance
Oregon grape is an evergreen shrub that typically grows 3-6 feet tall, forming dense colonies through underground rhizomes.
roots
Extensive rhizome system with bright yellow inner bark containing high concentrations of berberine and other alkaloids.
stem
Woody stems with smooth gray-brown bark. Inner bark is bright yellow and bitter-tasting.
leaves
Compound leaves with 5-9 holly-like leaflets, each with spiny margins. Leaves are leathery, glossy, and dark green, turning bronze-red in winter.
flowers
Bright yellow flowers arranged in dense, upright clusters (racemes) appearing in early spring before full leaf development.
fruits/seeds
Dark blue berries with a whitish bloom, resembling small grapes. Berries are edible but quite tart and contain 1-8 seeds.
Active Compounds
Traditional Uses
- Skin conditions and eczema
- Digestive inflammation and gastritis
- Infections and antimicrobial applications
- Liver and gallbladder support
- Arthritis and joint inflammation
- Eye infections and conjunctivitis
- Women's health and menstrual irregularities
Modern Applications
- Clinical treatment for psoriasis and atopic dermatitis
- Digestive disorders (GERD, gastritis, peptic ulcers)
- Antimicrobial infections (bacterial, fungal, parasitic)
- Anti-inflammatory conditions
- Blood sugar regulation support
- Sustainable alternative to goldenseal
⚠️ Safety Information
Contraindications
- Pregnancy and nursing (berberine concerns)
- Severe liver disease
- Hypoglycemia or diabetes medications (monitor blood sugar)
- Children under 2 years old
Side Effects
- Possible digestive upset with large internal doses
- Yellow staining of skin/clothing from fresh plant
- Rare allergic skin reactions with topical use
- Possible hypoglycemic effects
Drug Interactions
- May enhance effects of diabetes medications
- Potential interactions with blood-thinning medications
- May interfere with tetracycline antibiotics
- Caution with other berberine-containing herbs
Parts Used
- Root bark and inner bark (primary medicinal use)
- Occasionally berries for food and mild medicine
Preparation Methods
1-2 tsp dried root bark per cup water, simmer 15-20 minutes
1:5 ratio in 50% alcohol, 2-4 ml three times daily
Oil infusions, salves, and creams for skin conditions
Ground root bark in capsules, 500-1000mg daily
Mild preparation for digestive support
Related Plants
Blue Cohosh
Caulophyllum thalictroides
Aloe Vera
Aloe barbadensis
Birch
Betula spp.
Calendula
Calendula officinalis
Chamomile
Matricaria chamomilla
Licorice
Glycyrrhiza glabra